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Nature 634 , 919928 (2024)

[182] Dye BA, Schober SE, Dillon CF, Jones RL, Fryar C, McDowell M, et al

In such cases, factors like oxidative stress, chronic inflammation, and immune dysregulation may contribute to accelerated follicular depletion and endocrine failure (Hamoda and Sharma, 2024), forming the basis for the mechanisms explored in the following sections

Users should introduce retinoids gradually 2-3 times weekly, applying well away from lash line, and monitoring carefully for dryness or irritation requiring protocol adjustment