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The foundational preclinical study was published by Neelakantan et al

The blood-brain barrier, or BBB, consists of the endothelial cells lining the blood vessels in the brain

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Retatrutide is administered once weekly and in a phase 2 clinical trial, 36 weeks of treatment with retatrutide (doses ranged from 0.5 mg to 12 mg) resulted in up to 2.2% HbA1c reduction (with retatrutide 12 mg once weekly) compared to 1.4% with dulaglutide 1.5 mg and 0.3% with placebo [77]