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Crucial biological functions such as immune response, tissue repair, hormone production, etc

Carey RM, Wang ZQ, Siragy HM

Conclusion A series linear Ang IV analogues demonstrating improved metabolic stability and very high affinity to IRAP have been reported, e.g., the potent hexapeptides 11 (AL-11) and 12 (IVDE77) with Ki values of 7.6 and 1.7 nM, respectively, data to be compared with the Ki value of Ang IV of 62 nM in the same binding assay

The most common issues were nausea (20% to 47% depending on dose), followed by constipation, diarrhea, and abdominal discomfort

Catalpol not only alleviates LPS-triggered cognitive impairment in mice post-sepsis ( Catalpol mitigates lead-induced neurotoxicity in PC12 cells by inhibiting the JAK2/STAT3 signaling pathway