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Recently, a study demonstrated that leucine rich repeat containing 15 (LRRC15) displayed a more specific expression pattern in myCAFs, and targeted depletion of LRRC15 + myCAFs resulted in a substantial 70% reduction in overall PDPN + CAFs, significantly attenuating PDAC tumour growth [216]

Toxicol Appl Pharmacol 230:352357 Garca-Montalvo EA, Reyes-Prez H, Del Razo LM (2009) Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress

67 Mechanistic depth: Beyond outcome-based studies, scientists have delved into how BPC-157 achieves these effects

Wang H et al (2024) Interleukin-10: a novel metabolic inducer of macrophage differentiation and subsequently contributing to improved pregnancy outcomes of mice by orchestrating oxidative phosphorylation metabolism