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We previously found that a lower MeHg dose modifies Kelch-like ECH-associated protein 1 (Keap1) and phosphatase and tensin homolog deleted on chromosome ten (PTEN), thus leading to the activation of the Keap1/nuclear factor E2 related factor 2 (Nrf2) pathway and PTEN/Akt signaling, which are related to detoxication of xenobiotics and cell survival, respectively, whereas MeHg at a high dose disrupts cellular homeostasis, resulting in cell death 5,6

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Dopaminergic neurons locate principally in the ventral tegmental area (VTA), the substantia nigra pars compact (SNc) of the midbrain, and the arcuate nucleus of hypothalamus