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For example, those with severe liver or kidney impairment, unstable heart disease, or other significant systemic illnesses are typically approached carefully if considering NAD+ therapy

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The use of an effective dosage of vitamin B 12 over a period of time can prevent recurring of buccal, nasal, gastrointestinal, anal, and/or vaginal mucosal lesions or injury of any origin, regardless of serum Vitamin B 12 level [9]

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