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Full-length human growth hormone binds to growth hormone receptors distributed throughout the body, triggering a cascade of effects including stimulation of IGF-1 production in the liver, alterations in glucose and insulin metabolism, protein synthesis in muscle tissue, bone growth and remodeling, organ enlargement with prolonged use, and fluid retention

(1992) [12] in 16 patients with chronic insomnia studied over five laboratory nights

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Nguyen M, Wong YC, Ysselstein D, Severino A, Krainc D