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Efficacy of Nasal Testosterone Gel (Natesto()) Stratified by Baseline Endogenous Testosterone Levels

A phase 2 randomized, double-blind, placebo-controlled 7-day trial (NCT03051256) showed a favorable safety and tolerability profile of esmethadone in adults with MDD and inadequate response

The FDA mainly performs post-market activities, including safety inspections, adverse event monitoring, and product recalls

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Clamp AR, Schffski P, Valle JW, Wilson RH, Marreaud S, Govaerts AS et al (2008) A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer