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Pretreatment screening is advisable to check for the possible presence of liver disease in patients being considered for methotrexate treatment

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However, considering the relative contraindication of tranexamic acid in patients with bleeding/coagulation disorders, the use of oral glutathione is safer to be used in these categories of patients

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Candida overgrowth may worsen symptoms in people with Hashimotos, but it is not proven to cause the disease directly