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TB-500: 43 amino acids (Thymosin Beta-4 fragment), derived from thymus protein, primary mechanism is actin polymerization and cell migration, most studied for wound healing and cardiac repair

The sequence with its three consecutive proline residues at positions 3, 4 and 5 is structurally significant

PubMed 22962027 TB-4 Phase 1 human safety first-in-human randomized, double-blind, single- and multiple-dose Phase 1 of recombinant human thymosin 4 in healthy volunteers, no serious adverse events: PubMed 34346165

Mazdutide is actually already approved in China for overweight, and obesity in non-diabetics at 4mg and 6mg dose

Most research involves animal studies, and the Phase 1 human trial completed in 2015 never published results