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Karotenoidy jako naturalne antyoksydanty (Carotenoids as natural antioxidants) Postepy Hig

Two reasons are commonly cited: preventing receptor desensitization and avoiding copper accumulation

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J Biol Chem 270, 2268922692 (1995)

Overall, the core molecular machinery of ferroptosis is regulated by various cellular signalling pathways and genes but is primarily mediated through two main pathways, namely, extrinsic or transporter-dependent pathways (e.g., reduced cysteine or glutamine uptake and increased iron uptake) and intrinsic or enzyme-regulated pathways (e.g., inhibition of glutathione (GSH) peroxidase 4 (GPX4) antioxidant system) (Fig