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PT2385 binds to the PAS-B domain of HIF-2, a region crucial for heterodimerization with HIF-1 (ARNT), effectively preventing DNA binding and transcriptional activation of downstream oncogenic targets such as VEGF, cyclin D1, and GLUT1 (187)

The protective effect of garlic against DNA damage can be partially conserved by crushing garlic and allowing it to stand for 10 minutes prior to microwave heating for 60 seconds or by cutting the tops off garlic cloves and allowing them to stand for 10 minutes before heating in a convection oven

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