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References: Katzung BG (2021): Introduction to Autonomic Pharmacology (Chapter 6)

When the 60 mg vial makes financial sense You are at a maintenance dose of 7.5 mg or higher (you will use the vial within the stability window) You have already titrated using smaller vials and know your target dose You are comfortable with reconstitution and precise syringe measurements You can store the vial properly for the entire duration When smaller vials make more sense You are just starting tirzepatide and do not know your dose yet You are microdosing at very low amounts (1-2.5 mg) You want to test a new vendor or batch before committing to a large purchase Your storage conditions are not ideal (unreliable refrigeration, travel) Syringe selection and measurement precision The syringe you use matters more than most people realize

10.1016/j.isci.2024.109737 84 PontelL

This benefit has yet to be proven, but a recent analysis of clinical studies with cannabinoids may explain this effect, as discussed in the What It Does section of the CBD and Hemp Extracts Review

This, in turn, inhibited the uptake of As(III) into roots