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Risks and Unknowns Remaining research gaps include: Long-term systemic administration data Optimal dosing strategies outside dermatology Interaction with copper metabolism disorders Comparative efficacy versus standard wound treatments Most evidence supports local, tissue specific effects rather than systemic transformation

Front Neurol 12:656349 Acknowledgements For the purpose of open access, this paper has been published under the creative common licence (CC-BY)

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The available research does not identify one universally superior form