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When either or both of these processes are not functioning optimally, estrogen can be reabsorbed into circulation rather than eliminated, contributing to high levels of estrogen which will only worsen endometriosis

Peptides tend to work via an indirect path such as upregulating endogenous antioxidant pathways or enhancing mitochondrial repair

Because estrogen stimulates the endogenous synthesis of phosphatidylcholine via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, premenopausal women may be less likely to develop signs of choline deficiency in response to a low-choline diet compared to postmenopausal women (18, 19)

Mechanisms of Ageing and Development, 134 (7-8), 314-320

Abstract Tamoxifen is the accepted therapy for patients with estrogen receptor- (ER)-positive breast cancer