Mehanizam djelovanja Oralni BPC-157 djeluje lokalno i sistemski: Potie angiogenezu (stvaranje novih krvnih ila) u crijevnoj sluznici poboljava opskrbu kisikom i hranjivim tvarima Smanjuje upalu u probavnom sustavu ( TNF-, IL-6, COX-2, MPO) i titi mukoznu barijeru Ubrzava zacjeljivanje ulkusa, erozija, fistula i lezija (eludac, dvanaesnik, tanko i debelo crijevo) Normalizira proizvodnju eluane kiseline i zatitnih faktora (mucin, bikarbonat) titi od oksidativnog stresa i toksina (alkohol, NSAID, kemikalije) Poboljava integritet crijevne barijere (leaky gut) smanjuje propusnost i autoimune reakcije Za razliku od injekcijske forme (koja je sistemskija), oralni BPC-157 ima izuzetnu lokalnu aktivnost u GI traktu stabilan je u kiselom okruenju eluca i djeluje direktno na sluznicu prije apsorpcije
Gereduceerde glutathion (GSH) is de actieve vorm van glutathion
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However, around the age of 30, a person's need for glutathione surpasses their body's ability to produce it, largely due to increased exposure to harmful elements and a decrease in the production of necessary enzymes
4.6 Application of nano delivery system As plant polysaccharides possess biodegradability, biocompatibility, and inherent pharmacological activity, nanomaterials derived from plant polysaccharides exhibit significant advantages in improving drug utilization, pharmacokinetics, reducing toxicity, controlling drug release, and minimizing required dosages ( 2+ levels, reduced GSH, mitochondrial shrinkage and cristae disruption, upregulation of ferroportin, and downregulation of SLC40A1 and Ferritin, ultimately disrupting iron homeostasis ( 4.7 Stimulation of immune response against cancers Polysaccharides possess notable properties of immunomodulatory and anticancer, making them valuable therapeutic agents
