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Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic cells

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The GutBrainMitochondria Axis in Autism The process can be understood as a biological cascade: Gut dysbiosis imbalance in the microbiome Leaky gut increased intestinal permeability Microbial metabolites enter the bloodstream Neuroinflammation and oxidative stress occur in the brain Mitochondrial dysfunction affects neuronal development This interconnected system helps explain why many children with ASD experience gastrointestinal symptoms, immune irregularities, and metabolic differences alongside neurological symptoms

Additional information Responsible Editor: Gangrong Shi Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations