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In severe cases, we may consider using the intravenous medication pegloticase (Krystexxa), since it lowers the urate level the most dramatically, and can lead to the fastest shrinkage of the tophus

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Same observation, just now we can see the machinery behind it

and I.O.: formal analysis

Inflammation control (TB-500): TB-500 is often promoted as an anti-inflammatory peptide that could ease chronic soreness or help manage overuse injuries