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4.4 Supportive and adjunctive therapies Supportive and adjunctive therapies play a complementary role in addressing endometriosis-associated infertility by targeting underlying pathophysiological mechanisms such as oxidative stress, immune dysregulation, and pain

PMCID: PMC5601071

Whether CagriSema ultimately occupies a meaningful commercial position in the obesity market will depend substantially on how the FDA evaluates the REDEFINE evidence package and how payers and prescribers weigh a well-evidenced but second-ranked option against the existing approved standard.

Proposed mechanisms include enhanced insulinotropic activity, improved adipose tissue handling of nutrients, central effects on appetite and reward pathways, and improved tolerability or pharmacodynamic balance when combined with GLP-1 receptor agonism

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