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Separating this complex and potentially deadly internal gut content from our circulation and other organ systems, including the brain, is a tightly regulated interface consisting of a mucus layer, a single epithelial layer held together by tight junction proteins (e.g., zonulin and occludin), immunoglobulin A, defensins, and a carefully orchestrated immune surveillance in the lamina propria of the gut [136]

Its selective signaling profile makes it a valuable tool for researchers studying targeted metabolic pathways, adipose dynamics, and peptide-driven energy regulation

Cell 181 , 10161035.e19 (2020)

Albers James W, Chaudhry V, Cavaletti G, Donehower Ross C (2011) Interventions for preventing neuropathy caused by cisplatin and related compounds