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Moreover, anti-MMP-9 antibody treatment in C3HeB/FeJ mice led to the development of hypoxic TB granulomas and cavitary lesions, resulting in a lower relapse rate, although this was not significantly different [138]

These doses were chosen based on in vitro tests of cytotoxicity using macrophages and peripheral blood mononuclear cells

While the study points to CACs potential role in infertility, no direct causal mutations linking CAC to fertility dysfunction have been confirmed yet

Cyanocobalamin is given through intramuscular or subcutaneous injections