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However, some studies propose a biphasic effect of iron status on OA progression, where iron overload and deficiency increase OA risk (Kennish et al., 2014)

Subclinical magnesium deficiency is extraordinarily common in elderly populations, driven by reduced dietary intake, increased renal excretion, medication interactions (particularly with proton pump inhibitors and diuretics), and diminished intestinal absorption

doi: 10.3390/ijms20061305 76 Hurtado-NuezGECorts-RojoCSnchez-CejaSGMartnez-FloresHESalgado-GarcigliaRBartolom-CamachoMCet al

Development History The foundational work on IGF-1 LR3 emerged from pharmaceutical research in the 1990s aimed at developing IGF-1 analogs with improved pharmacological properties