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Treasure Island (FL): StatPearls Publishing, 2020

It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate

The lack of FDA approval for human use and the need for higher doses in some experimental settings underscore the importance of evaluating safety and efficacy under strict medical supervision

Next, they gently swirl the solution instead of shaking it, which protects peptide integrity

Figure 6 Reactive electrophiles, such as monobromobimane are detoxified by direct conjugation to BSH or by conjugation reactions catalyzed by BSH S -transferases