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That makes a true overdose very uncommon

Clinical guidance for intramuscular injections points to a 22 to 25 gauge needle, given at a 90-degree angle, with the length chosen so it reaches muscle without going too deep

Pregnancy and breastfeeding, unless specifically cleared by a physician due to unknown effects

Hold the syringe like a pencil in your dominant hand at a 90-degree angle to the B12 injection site, and insert the needle into the skin until you feel a little pop, a sign youve reached subcutaneous tissue

Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12