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High-quality large-scale clinical trials validating systemic effects in humans (e.g., for recovery optimisation or musculoskeletal outcomes) remain limited

Zhang CL, Zou Y, He W, Gage FH, Evans RM

the focus will be different, so these effects might not be as potent (or immediate), but they still may occur

This is especially helpful for aging skin, since they naturally decrease as we get older

(2) Behzad Nasseri, Jalal Zaringhalam, Samira Daniali, Homa Manaheji, Zahra Abbasnejad, Vida Nazemian, Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways, International Immunopharmacology, Volume 70, 2019, Pages 225-234