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After 12 weeks of treatment with EGCG + RES (282 + 80 mg/day), the diet-induced improvement in MetS associated with the gut microbiota was more easily observed in obese or overweight men, confirming sex differences in cardiovascular metabolic improvement [219]

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Many patients report feeling more energized and focused within days of their treatment

10.1038/ki.2012.475 42 PanS

On the other hand, substance P and calcitonin-gene-related-neuropeptide are well known neuropeptides in the induction of peripheral neuropathy and nociception