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The resulting surge in ROS leads to oxidative stress, a state where the production of oxidants overwhelms the cells antioxidant defense systems [97]

2j), corroborating the data shown in Fig

J Clin Endocrinol Metab 2009;94:96572.ArticlePubMed 16

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Conjugated bile acids had been previously identified as markers of cholecystectomy in sickle cell patients, 42 though the impact of patients genotypes, transfusion events or hydroxyurea treatment on the circulating levels of these metabolites had not been reported