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Reactive oxygen species (ROS), together with reactive nitrogen species (RNS), represent the most important prooxidants whose excessive accumulation leads to oxidative stress (OxS) and molecular damage ( ROS are crucial in thyroid function because they are essential in the initial stages of thyroid hormone synthesis during iodide oxidation ( Aerobic organisms have evolved multiple antioxidant and repair systems for protection against OxS

Mitochondria are the powerhouses of your cells, responsible for creating energy

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The same publication also detected an increased abundance of the genus Colidextribacter in patients with impaired intestinal permeability [38]: this taxon has previously been described to play a role in the increase of cellular oxidative stress capacity in a mice model, thus contributing to gut barrier impairment [38]

Mutation of this enzyme leads to fumarate accumulation not only in skin cancer and uterine leiomyomas but also in breast, bladder, and Leydig cell tumors 130