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Other reported side effects have been mild muscle fatigue or feeling chilled during a long infusion, which likewise tend to subside afterward

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10.15252/embj.201488349 EMBO J

In certain embodiments, the pharmacokinetics of the otic formulations or compositions described herein are determined by injecting the formulation on or near the round window membrane of a test animal (including by way of example, a guinea pig, a chinchilla, or a rat)