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Psychol Bull 2003;129(6):946972

Figure 4 Alterations in the intracellular redox status are often associated with GSH depletion (Polonikov, 2020) and endogenous GSH deficiency, due either to decreased biosynthesis and/or increased consumption, is a marked contributor to the pathogenesis of numerous diseases via mechanisms including oxidative stress and inflammation

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Controls were set up using comparable reaction conditions with shelterin and 300 M of the inactive control compound 60 or TRF1 only (without ligand)