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To enhance the oral absorbtion of the drug, metformin prodrugs were developed with improved permeability across the lipid membrane 120

Signal transduction by reactive oxygen species

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In particular, miR-132 has been shown to promote neuronal survival and morphogenesis by targeting IL-1 receptor-associated kinase, thereby suppressing astrocyte-derived proinflammatory cytokine secretion and fostering a neuroprotective environment 132