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Because the peptide rebuilds tissue gradually, steady use and the right supporting care matter more than expecting a fast change

[DOI] [PubMed] [Google Scholar] 97.Manley R.C

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However, with the prevalence of skin permeation enhancement methods (such as microneedles and laser) used in cosmetic and pharmaceutical industry 15 , copper compounds may pose a higher risk to cause skin irritation, which necessitates a thorough skin toxicity testing

Olszewska-Pazdrak B, Hein TW, Olszewska P, Carney DH (2009) Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells