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Just as we prioritize SAEs in drug safety, Materiovigilance demands rapid action to ensure a faulty batch or a design flaw doesn't impact more patients

The documentation is comprehensive, which is vital for publication standards

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In biochemical assays, the T98I and W207L/R substitutions did not affect nirmatrelvir activity (Ki value fold changes were 0.3 and 0.7/0.3, respectively), whereas the E166V substitution (which occurs at a Mpro-nirmatrelvir contact residue) reduced nirmatrelvir activity 187-7,700-fold

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