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*Correspondence: Hang Lin, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Tissue Engineering and Regenerative Medicine, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This observation could possibly be explained by the accumulation of AGEs disrupting the regular force-transferring mechanisms of collagen fibrils

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However, due to the difference in the natural history of the two forms of chronic liver failure and ALF, NAC has been less studied in patients with ALF