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MOTS-c acts as a metabolic coordinator, linking mitochondrial health to nuclear gene expression, a critical communication system that often fails during aging and metabolic disease

Recently, NRF2 and ATF4 deficiency was shown to reduce SLC7A11 levels resulting in improved cancer cell survival under low glucose conditions

[PubMed] [Google Scholar] 25.Adeoye O., Olawumi J., Opeyemi A., Christiania O

Thus, developing new drugs based on this techniqueparticularly for minimally invasive therapyis a key focus of current research

Studies have shown that this condition is not only associated with impaired sperm production but also with a decreased number of spermatozoa successfully transported through the male reproductive tract (Hiroshige et al., 2024)