Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB
This metabolic reprogramming leads to the continuous production and accumulation of large amounts of lactate, which in turn causes acidification of the TME, promoting cancer cell growth, migration, and angiogenesis ( In addition, glucose transport plays a crucial role in regulating tumor glycolysis
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doi: 10.1089/ars.2016.6925