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Adverse events that may occur with methotrexate include rash, nausea, mucositis, diarrhea, bone marrow suppression, infections, pneumonitis, increased liver enzyme levels, and liver fibrosis or cirrhosis

Although one of the potential limitations of translating cortistatin-based therapies to the clinical practice is its peptidic nature and low stability in physiological fluids, the interest of the pharmaceutical industry in protecting it and improving its bioavailability has considerably increased lately

Sample sizes were 6-14 subjects

In dogs with liver disease, glutathione concentrations in liver tissue have been shown to be altered, which helps explain why antioxidant status may matter in hepatic conditions

Without this specificity, coders face a dilemma: assign the more general D51.9 (unspecified B12 deficiency anemia) or query the provider