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Fatih Terzi (Istanbul Technical University) 327 Urban Digital Twins for Cities in Transition: A Literature Review on Current Applications and Future Perspectives Cities in transition are urban environments undergoing profound transformations to address some of the most pressing global challenges, including climate change, socio-economic inequality, rapid urbanization, and the urgent need for sustainable development

When bilirubin acts as an antioxidant it is converted into biliverdin

Observations indicate potential modulation of protoporphyrin accumulation[13]

Such high metabolic demand to produce and secrete insulin can render the -cells susceptible to exceeding ER protein folding capacity, in turn leading to accumulation of misfolded proteins and ER stress (35)

A few more data points are worth keeping in view because they round out the safety story