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conducted a retrospective cohort study involving 20975 patients (4195 GD patients and 16780 non-GD patients) and discovered that GD and GD treatment are associated with an increased risk of depression in Asian patients ( Although our screening results have already supported a strong link between GD and depression, the number of current clinical studies available remains very limited

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and Hondur et al

The answer- it depends

Dysfunction of System Xc , depletion of GSH, or inhibition of GPX4 activity can lead to the accumulation of iron-dependent lipid peroxides, ultimately initiating ferroptosis (Guo et al., 2025a)