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Intrinsic factor, a protein that shuttles B12 through the absorption process, becomes saturated after a meal containing an above-average amount of B12 and about 4 to 6 hours are required before it can efficiently absorb another dose (IOM, 1998)

The most common B12/MIC side effect is pain, redness, or itching at the injection site

You can have vitamin B12 deficiency anemia if you don't get enough vitamin B12 in your diet from foods like milk, eggs, and meat, or if your body can't absorb B12 because of a health problem

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for this reason, some clinicians recommend an intradermal test dose in individuals who may be at risk of thiamine allergy