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Furthermore, the influence of H.p reaches distant organs via axes such as the gut-lung axis, where infection in infancy can alter the lung microbiome and associated inflammation (Siegel et al., 2024), and the microbiota-gut-brain axis, thereby increasing the risk of neurological disorders such as post-stroke depression (Sun et al., 2024

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Furthermore, in acquired models of 5FU resistance that show mitochondrial dysfunction, combination of ETC CI inhibition (by metformin and others) and 5FU treatment increased tumour control