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Signs and symptoms of overdosage reported with sulfonamides include anorexia, colic, nausea, vomiting, dizziness, headache, drowsiness and unconsciousness

Need for in vivo documentations in humans The above mentioned studies are mainly based on in vitro and preclinical data, while the field would largely benefit from a more solid documentation of the capacity of riboflavin-producing organisms to increase riboflavin in vivo in humans by for example metagenomic/proteomic/metabolomic studies of the gut and vaginal microbiomes