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Major Criteria Family history of vEDS with a documented causative variant in COL3A1 Arterial rupture at a young age Spontaneous sigmoid colon perforation in the absence of known diverticular disease or other bowel pathology Uterine rupture during the third trimester in the absence of previous C-section and/or severe peripartum perineum tears Carotid-cavernous sinus fistula (CCSF) formation in the absence of trauma Minor Criteria Bruising unrelated to identified trauma and/or in unusual sites such as the cheeks and back Thin, translucent skin with increased venous visibility Characteristic facial appearance Spontaneous pneumothorax Acrogeria Talipes equinovarus Congenital hip dislocation Hypermobility of small joints Tendon and muscle rupture Keratoconus Gingival recession and gingival fragility Early-onset varicose veins (under age 30 and starting before pregnancy if female) If a person meets the diagnostic criteria for aEDS, genetic testing should be done to confirm the diagnosis

Subsequent mass spectrometry analysis of biotin-captured proteins revealed that FBXO22 was the strongest interactor

Oxidative stress has been shown to influence sleep regulation through its effects on neurotransmitter systems, particularly those involving GABA and serotonin (Tsermpini et al

Intranasal GSH has shown potential to raise brain GSH levels (Aoyama & Nakaki, 2021)

Rho Nutrition was founded by Ryan Bishop and George Padilla to raise the standard of modern supplementation