However, long-term human safety data from controlled clinical trials is limited
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Active cancer or recent cancer history : NNMT plays a complex role in cancer biology
It acts as a free radical scavenger, upregulating antioxidant enzymes such as superoxide dismutase and catalase (9)
The "maintained improvements" group (approximately 30-40% of users) reports substantial benefit retention 6-12 months post-discontinuation, typically characterized by users who completed 6+ month treatment courses using adequate concentrations (1-2% GHK-Cu), maintained consistent application patterns, addressed underlying skin damage during treatment allowing structural improvements, optimized complementary skincare including sun protection and moisturization, maintained healthy lifestyle supporting collagen synthesis including adequate protein intake and sleep, and possessed favorable genetics for collagen production and skin aging resistance
