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It decreases the folic acid reservoir which consequently induces several pathological events associated with oxidative stress, inflammation, apoptosis, and fibrosis ( The impairment of the tissue oxidant/antioxidant balance remains the hallmark cause of MTX-induced organ toxicity resulting in oxidative damage ( The pathogenesis of MTX-induced hepatotoxicity ( Conversely, MCP significantly rebalanced the oxidative status in both tissues, indicating its antioxidant properties

There is limited clinical data on high-dose glutathione supplementation during lactation

It has a good safety profile and is allowed to be used at a max concentration of 5% both in the US and in Europe (10% is allowed in Japan)

The healthy chondrocytes, however, remained intact