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Abstract Colorectal cancer (CRC) chemotherapy remains clinically challenging due to the emergence of drug resistance, off-target toxicity, and suboptimal patient compliance, underscoring the need for innovative, patient-centric delivery systems specially designed for targeted CRC therapy

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The positive impact on memory appears to support the hypothesis of enhanced hippocampal and medial temporal lobe function in patients adhering to a low-carbohydrate diet [184], as ketone metabolism may offer particular benefits for these brain structures [185]

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Cation-pi interactions were observed in five complexes between an aromatic ring of a fragment and either R102 or R131 (Fig