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Notably, although plant metabolites such as berberine, emodin and curcumin have been shown in vitro to improve NAFLD symptoms by regulating hepatic lipid metabolism and inhibiting hepatocellular inflammation, they are categorized as pan-assay interference compounds (PAINS), which may generate false-positive results in vitro through non-specific mechanisms (Magalhes et al., 2021)

GHK administered intraperitoneally at doses of 2.6, 26, and 260 g/ml/day reduced inflammatory cell infiltration, levels of TNF- and IL-6, as well as abolished bleomycin-induced elevation of TGF-beta in bleomycin-induced lung fibrosis in mice

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