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Analysis of pooled data To increase the sample size and BW range, five independent experiments totalling 145 rats were pooled into vehicle (V, n = 38), drug (CS + C + S, n = 57) and calorie restriction (WM + PF, n = 50) groups (Extended Data Table 1)

Proteins usually refer to denote an entire biological molecule in a stable conformation, while peptides refer to short amino acid oligomers most commonly lacking a stable 3-dimensional structure

By contrast, when supernatant of PCA extract snap frozen in liquid nitrogen (F

This is particularly beneficial in personalized medicine, where inter-patient variability in drug metabolism and immune responses can greatly influence therapeutic success

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