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Its molecular structure was optimized through genetic engineering technology: an additional 13 amino acids were added to the N-terminus of natural IGF-1 (70 amino acids, molecular weight 7.4 kDa) to form a long-chain structure of 83 amino acids (molecular weight 9.11 kDa), and the third glutamic acid (Glu) was replaced with arginine (Arg), hence the name "R3"

255 Siah1, a critical link between p53 and Wnt/-catenin signaling, regulates -catenin turnover independently of GSK3, and its dysfunction contributes to CRC progression

Astrocyte state transitions: balancing protection and pathology Traditionally, neuronal plasticity has been regarded as the principal mechanism underlying adaptive responses in the CNS, encompassing synaptic remodeling and circuit reorganization that support learning and memory

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Complete immobilization produces weak, disorganized repair tissue while progressive loading promotes strong, aligned structures