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There is only the case of the nuclear transcription factor c-Jun that, due to an unusual redox potential, could react with GSSG at relatively high ratio of GSH/GSSG = 13 ( S -glutathionylation within the cells involves reaction of the critical cysteine on protein or GSH with a corresponding oxidized derivative such as S-nitrosyl ( S -NO), sulfenic acid ( S -OH), thiyl radical ( S )

Blocking the interaction between PIN-1 and MAT1 reversed the alcohol-induced cytotoxic phenotype

However, cooking methods play an important role in the amount of glutathione it provides